About the Drug

Anafranil (Clomipramine) is used to treat obsessive-compulsive disorder. It works by increasing the brain chemical serotonin to help maintain mental balance.

Use of Information is providing this information solely & freely for educational purposes. Always seek professional consult with your healthcare provider if you have any questions or concerns. This information can be used as an educational guide, however not every drug interaction or side effect may be listed.

Proper Usage

Anafranil comes in capsule form and is usually taken 2-3 times per day with meals at the beginning of treatment. After several weeks it can be taken once per day at bedtime. It may take several weeks before you get the full effect of the medication.

What If I Missed a Dose?

In the case that you miss taking your medicine, it is recommended that you take it when you remember. It is NOT advised to “double dose” (taking both your missed dose and your next one). What’s most important is you get back to your medication regime and avoid missing doses without professional consult.

How Can I Store this Medicine?

This medication should be stored at room temperature away from light, heat and moisture.

Possible Side Effects

The side effects associated with Anafranil should lessen as your body adjusts to the medication. Inform your doctor if they persist or get worse.

  • drowsiness
  • dry mouth
  • nausea
  • vomiting
  • diarrhea
  • constipation
  • nervousness
  • decreased sexual ability
  • decreased memory/concentration
  • headache
  • stuffy nose
  • change in appetite or weight

The following symptoms should be addressed immediately by calling your physician.

  • uncontrollable shaking of a part of the body
  • seizures
  • changes in heart rhythm
  • difficulty urinating/loss of bladder control
  • believing things that are not true
  • hallucinations
  • eye pain
  • shakiness
  • difficulty breathing or fast breathing
  • severe muscle stiffness
  • unusual tiredness or weakness
  • sore throat, fever, and other signs of infection


Tell your doctor if you have any of the following medical conditions. Taking Anafranil can increase the symptoms associated with these disorders.

  • heart disease/heart attack/stroke/seizures
  • bipolar disorder/schizophrenia
  • kidney or liver disease
  • overactive thyroid
  • glaucoma
  • problems with urination

Took an Overdose?

If you or someone you know took an overdose of this medication, then you need to IMMEDIATELY seek medical attention.

Hotline: U.S. National Poison Control 1800-222-1222

Other Drug Interactions

Anafranil can react with other medications so always tell your doctor about any medications you are taking. Severe reactions can occur with the following medications. This list is not all inclusive.

  • Coumadin
  • Cogentin
  • Tagamet
  • Haldol
  • Concerta/Metadate/Ritalin
  • Prozac/Sarafem/Zoloft
  • Fluoxetine